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Furthermore, whereas administration of either [ 35 S]-Met or [ 35 S]-cystine resulted in rapid [ 35 S]-labeling of hepatic GSH and protein pools in control mice, only administration of [ 35 S]-Met, not [ 35 S]-cystine, appreciably radiolabeled either hepatic GSH or protein pools in mice with TrxR1/Gsr-null livers [107]